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Reeves R. Molecular biology of HMGA proteins: hubs of nuclear function. Gene — HMGA molecular network: from transcriptional regulation to chromatin remodeling. Biochim Biophys Acta — HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis. BMC Genomics EMBO J — A novel mechanism of post-translational modulation of HMGA1 functions by the histone chaperone nucleophosmin. Sci Rep Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer.

Cancer Res — Mol Cell Biol — Endocr Relat Cancer — Mol Endocrinol — Int J Biochem Cell Biol — Front Endocrinol HMGA1 is a novel downstream nuclear target of the insulin recptor signaling pathway. Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in human and mice. Nat Med — Pseudogene-mediated posttranscriptional silencing of HMGA1 can result in insulin resistance and type 2 diabetes. Nat Commun Evidence that an HMGA1 gene variant associates with type 2 diabetes, body mass index, and high-density lipoprotein cholesterol in a Hispanic-American population.

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Metab Syndr Relat Disord The association between HMGA1 rs variant and type 2 diabetes: a transethnic meta-analysis. PLoS One A polymorphism of HMGA1 is associated with increased risk of metabolic syndrome and related components. HMGA1 overexpression in adiose tissue impairs adipogenesis and prevents diet-induced obesity and insulin resistance. Oncogene — Role of activating protein-1 and high mobility group-I Y protein in the induction of CD44 gene expression by interleukin-1beta in vascular smooth muscle cells.

Is Diabetes Completely Genetic?

HMGA1 proteins in human atherosclerotic plaques. Pathol Res Pract —7. High-mobility group A1 protein: a new coregulator of peroxisome proliferator-activated receptor-gamma mediated transrepression in the vasculature. High glucose-induced expression of proinflammatory cytokine and chemokine genes in monocytic cells. Ceriello A.

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Vascul Pharmacol —8. Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells. Genome Res 21 10 — Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.

Genetics of Diabetes | ADA

Epigenetic changes in diabetic and cardiovascular risk. Clinical applications of epigenetics in cardiovascular disease: the long road ahead. Transl Res — Augmentation of histone deacetylase 3 HDAC3 epigenetic signature at the interface of proinflammation and insulin resistance in patients with type 2 diabetes. Clin Epigenetics Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PLoS One 5:e The FTO gene rs polymorphism predict risk of cardiovascular disease: a systematic review and metanalysis.

PLoS One 8:e IGF2 methylation is associated with lipid profile in obese children. Horm Res Paediatr —7. The epigenetic signature of systemic insulin resistance in obese women.

Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes. An analysis of DNAmethylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss.


Can diabetes be passed down in the genes?

Genome Biol Epigenetic regulation of macrophage polarization by DNAmethyltransferase 3b. Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction. Int J Epidemiol — MicroRNAs in cardiovascular disease: an introduction for clinicians.

Heart —8. Hashimoto N, Tanaka T. Role of miRNAs in the pathogenesis and susceptibility of diabetes mellitus. J Hum Genet — Recent progress in genetic and epigenetic research on type 2 diabetes. Exp Mol Med e MicroRNAs and cardiovascular disease in diabetes mellitus. Biomed Res Int Differentially expressed microRNAs and their target genes in the hearts of streptozotocin-induced diabetic mice.

Mol Med Rep — Oscillating glucose induces microRNA and impairs an efficient antioxidant response in human endothelial cells. Molecular interplay between microRNAa and sirtuin1 in hyperglycemia-mediated impaired angiogenesis in endothelial cells: effects of metformin. J Pharmacol Exp Ther — Vascular microRNA is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating sirtuin1. The endothelial-specific microRNA miR governs vascular integrity and angiogenesis. Dev Cell — Sci Signal 2:ra Vascul Pharmacol — Down-regulation of proangiogenic microRNA and microRNA are early modulators of diabetic cardiac microangiopathy.

Cardiovasc Res — Circ Res —7.

Worthless or valuable?

Circulating microRNAs in patients with coronary artery disease. MicroRNA contributes to glucose-induced endothelial cell dysfunction and this effect can be reversed by far-infrared irradiation. MicroRNAa regulates autophagy of endothelial progenitor cells through Runx3. Clin Exp Pharmacol Physiol —7. MicroRNA regulation of vascular smooth muscle function and phenotype: early career committee contribution. Arterioscler Thromb Vasc Biol —6. MiR and miR regulate smooth muscle cell fate and plasticity.

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Regulation of vascular smooth muscle cell dysfunction under diabetic conditions by MIR Arterioscler Thromb Vasc Biol — MicroRNA finetunes the expression of key FOXA2-activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes. Diabetes —8. Eur J Pharmacol — MicroRNAa regulates insulin sensitivity and metabolism of glucose and lipids. J Clin Invest — Grove EL, Gregersen S. Antiplatelet therapy in patients with diabetes mellitus.

Curr Vasc Pharmacol — Existence of a microRNA pathway in anucleate platelets. Nat Struct Mol Biol —6. The complex transcriptional landscape of the anucleate human platelet. Exosomal miRNAs in heart disease. Physiology Bethesda — Detection of platelet microRNA expression in patients with diabetes mellitus with or without ischemic stroke. Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes. Modulation of circulating microRNAs levels during the switch from clopidogrel to ticagrelor. Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent manner.

J Neurochem — Thromb Haemost — The emerging role of miR in platelet reactivity: implications in antiplatelet therapy. Decreased circulating microRNA level predicts high on-treatment platelet reactivity in patients with troponin-negative non-ST elevation acute coronary syndrome. J Thromb Thrombolysis — Platelet-derived miRb as a novel biomarker for the early diagnosis of type 2 diabetes. Acta Diabetol —9. Mills CD. M1 and M2 macrophages: oracles of health and disease.

Crit Rev Immunol — Distribution of macrophage polarization markers in human atherosclerosis. Atherosclerosis —8. MicroRNAb improves glucose homeostasis and insulin sensitivity by regulating endothelial function in white adipose tissue. Increased microRNA-1 and microRNAa levels in serum of patients with cardiovascular disease indicate myocardial damage. Circ Cardiovasc Genet — MicroRNA controls cardiac hypertrophy.

Nat Med —8. Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells. J Mol Cell Cardiol — Cardiovascular microRNAs: as modulators and diagnostic biomarkers of diabetic heart disease. Lack of miRa decreases contractility of diabetic hearts: a role for novel cross talk between tyrosine aminotransferase and tyrosine hydroxylase.

Transcoronary concentration gradient of microRNAa and outcome in patients with coronary artery disease. Am J Cardiol — Stem Cells Dev — The high mobility group A proteins contribute to thyroid transformation by regulation miR and miRb expression. Mol Oncol — J Mol Biol — Lee JT. Epigenetic regulation by long noncoding RNAs. Science —9. Fatica A, Bozzoni I. Long non-coding RNAs: new players in cell differentiation and development. Nat Rev Genet — Molecular mechanisms of long noncoding RNAs. Mol Cell — Esteller M.